Vitenskapelige publikasjoner

Modulation of posterior insula selectively enhances nociceptive sensory gating in healthy humans

Legon, Wynn; Isaac, Gabriel; Kapoor, Aditya; Strohman, Andrew

Neurobiology of Pain, 20, 100220. DOI: 10.1016/j.ynpai.2026.100220

Does intra-epidermal electrical stimulation activate mechano- and thermo-nociceptors? A discrimination approach

Júlio, S.U.; Schneuwly, M.; Scheuren, P.S.; Hubli, M.; Schubert, M.

Journal of Neuroscience Methods, 416, 110382. DOI: 10.1016/j.jneumeth.2025.110382

Test–retest reliability of intra-epidermal electrically evoked potentials in comparison with other modalities and across stimulation intensities

Júlio, Sara U.; Rüegge, Pascale; Schneuwly, Miriam; Hong, Kevin; Hubli, Michèle; Schubert, Martin

Scientific Reports, 15(1), 37998. DOI: 10.1038/s41598-025-21815-8

The effect of stimulus saliency on the modulation of ongoing neural oscillations related to thermonociception: A registered report

Leu, Chiara; Forest, Sébastien; Legrain, Valéry; Liberati, Giulia

Cortex, 185, 316-335. DOI: 10.1016/j.cortex.2025.02.009

High-speed heating of the skin using a contact thermode elicits brain responses comparable to CO2 laser-evoked potentials.

Lejeune N., Petrosova E., Frahm K.S, Mouraux A.

Clinical Neurophysiology. 146, 1-9.

Confidence of probabilistic predictions modulates the cortical response to pain

Mulders, Dounia; Seymour, Ben; Mouraux, André; Mancini, Flavia

Proceedings of the National Academy of Sciences, 120(4), e2212252120. DOI: 10.1073/pnas.2212252120

Improved acquisition of contact heat evoked potentials with increased heating ramp.

De Schoenmacker I., Archibald J., Kramer J.L.K. & Hubli M.

Scientific Reports , 12, 925.

Cold evoked potentials elicited by rapid cooling of the skin in young and elderly healthy individuals.

Scheuren P.S., Nauer N., Rosner J., Curt A., Hubli M.

Science Report, 12:4137.

Combining Topical Agonists With the Recording of Event-Related Brain Potentials to Probe the Functional Involvement of TRPM8, TRPA1 and TRPV1 in Heat and Cold Transduction in the Human Skin.

Courtin A. & Mouraux A.

The Journal of Pain. Epub, 1-18.

A modality-specific somatosensory evoked potential test protocol for clinical evaluation: A feasibility study.

Fabig S.C, Kersebaum D., Lassen J., Sendel Manon, Jendral S., Muntan A., Baron R. & Hüllemann P.

Clinical Neurophysiology. 132, 3104-3115.

Dynamics of perception and EEG signals triggered by tonic warm and cool stimulation.

Mulders D., de Bodt C., Lejeune N., Courtin A., Liberati G., Verleysen M., Mouraux A.

Plos One , 15(4).

Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber-mediated heat sensitivity.

van Neerven S.G.A. and Mouraux A.

Frontiers in Pharmacology . 11, 1-15

Conduction velocity of the cold spinal pathway in healthy humans.

Leone C., Di Lionardo A., Diotallevi G., Mollico C, Di Pietro G., Di Stephano G., La Cesa S., Cruccu G., Truini A.

European Journal of Pain. Online ahead of print doi: 10.1002/ejp.1640.

Insular response to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG.

Liberati G., Mulders D., Algoed M., van den Broeke E., Ferrao Santos S., Géraldo Ribeiro Vaz J., Raftopoulos C., Mouraux A.

Scientific Reports. 10:22319, 1-14.

Event-related brain potentials elicited by high-speed cooling of the skin: A robust and non-painful method to assess the spinothalamic system in humans.

De Keyser R., van den Broeke E., Courtin A., Dufour A., Mouraux A.

Clinical Neurophysiology. 129(5), 1011-1019.

Deep continuous theta burst stimulation of the opercula-insular cortex selectively affects Adelta fibre heat pain.

Lenoir C., Algoet M. & Mouraux A.

The Journal of Physiology. 596(19), 4767-4787.

Normative values for contact heat and cold evoked potentials.

Foolchand Y., Kuzminova A., Louis MH., Courtin A., Dessart P., Mouraux A., Hatem S. M.

European Journal of Pain.

Modulation of pain by affective touch: effects of childhood trauma, depression, chronic pain, and spinal segment

Albinni, Benedetta; Zimmerman, Marisa; Alasha, Vincent; Ross, Jacob; Crankshaw, Lindsey; Jones, Emrys; Lewis, Jeffery; Hu, Sandy R.; Schuster, Nathaniel; Case, Laura

The Journal of Physiology, JP290242. DOI: 10.1113/jp290242

Protokoll

Determination of central pain modulation biomarkers to characterise patients with cancer and refractory pain: protocol for a cross-sectional study

Rubal-Otero, Lara; Martinez-Rodriguez, Natalia; Álvarez-Rodríguez, Margarita; González-Villar, Alberto; Carrillo-de-la-Peña, María T

BMJ Open, 16(10), e121471. DOI: 10.1136/bmjopen-2026-121471

Protokoll

Assessing central nervous system contributions to accelerate musculoskeletal pain diagnosis and treatment (AsCent): protocol for a mixed-method, prospective observational study

Clay, Georgia; Vanhegan, Stevie; Abbott, Caroline; Pearce, Fiona A; Moffatt, Fiona; Bannister, Kirsty; Graven-Nielsen, Thomas; Walsh, David A; Smith, Stephanie L

BMJ Open, 16(5), e115860. DOI: 10.1136/bmjopen-2025-115860

Protokoll

Pain and Nutrition in Dementia and Alzheimer’s Phase 1: a cross-sectional, observational study design

Judkins, Taylor C.; Andrews, Hailey J.; Song, Qianqian; Clark, Edward I.; Tate, Camesha; Wais, Joshua I.; Fillingim, Roger; Huo, Zhiguang; DeKosky, Steven T.; Gower, Barabara; Cohen, Ronald A.; Ebner, Natalie C.; Cruz-Almeida, Yenisel; Strath, Larissa J.

Frontiers in Dementia, 5, 1789761. DOI: 10.3389/frdem.2026.1789761

Protokoll

Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study

De Lott, Lindsey B; Harte, Steven E; Kaplan, Chelsea; Williams, David A; Shtein, Roni; Woodward, Maria A; Tsodikov, Alexander; Deveney, Tatiana; Galor, Anat; Shea, Anne; Schultz, Charles; McKolay, Clare; Scott, Kathy A; Clauw, Daniel J

JMIR Research Protocols, 15, e84240. DOI: 10.2196/84240

Preprint — ikke fagfellevurdert

Safety and Tolerability of Low Intensity Focused Ultrasound to the Anterior Insula in Patients with Fibromyalgia

Kapoor, Aditya; Ni, Yunruo; Isaac, Gabriel; Keyes, David C.; Russo-Stringer, Elizabeth A.; Legon, Wynn

medRxiv. DOI: 10.64898/2026.06.01.26354382

Pain perception in autism. A study of sensory reactivity in children and adolescents with autism using quantitative sensory testing and psychophysiological correlates

Nicolardi, Valentina; Fanizza, Isabella; Accogli, Giuseppe; Scoditti, Sara; Trabacca, Antonio

Frontiers in Neuroscience, 19, 1543538. DOI: 10.3389/fnins.2025.1543538

A multi-modal evaluation of experimental pain and psychological function in women with carpometacarpal osteoarthritis

Ordonez Diaz, Tamara; Vasilopoulos, Terrie; Wright, Thomas W.; Cruz-Almeida, Yenisel; Nichols, Jennifer A.

Osteoarthritis and Cartilage Open, 6(4), 100515. DOI: 10.1016/j.ocarto.2024.100515

Subcutaneous Oxytocin Injection Reduces Heat Pain: A Randomized-Controlled Trial

Albinni, Benedetta; Zimmerman, Marisa; Ross, Jacob; Ozdoyuran, Leyla; Alasha, Vincent; Schuster, Nathaniel M.; Said, Engy; Case, Laura

The Journal of Pain, 25(9), 104547. DOI: 10.1016/j.jpain.2024.104547

Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity

Li, Wei; Pucka, Andrew Q.; Debats, Candice; Reyes, Brandon A.; Syed, Fahim; O’Brien, Andrew R.W.; Mehta, Rakesh; Manchanda, Naveen; Jacob, Seethal A.; Hardesty, Brandon M.; Greist, Anne; Harte, Steven E.; Harris, Richard E.; Yu, Qigui; Wang, Ying

Frontiers in Immunology, 15, 1288187. DOI: 10.3389/fimmu.2024.1288187

Protokoll

Validity of central pain processing biomarkers for predicting the occurrence of oncological chronic pain: a study protocol

Carrillo-de-la-Peña, M. T.; Fernandes, C.; Castro, C.; ; Rubal, Lara; Samartin-Veiga, Noelia; Yarnitzsky, David; Arendt-Nielsen, Lars; Dahl, Carsten; Medeiros, R.

BMC Cancer, 24(1), 705. DOI: 10.1186/s12885-024-12455-8

Cold-evoked potentials in clinical practice: A head-to-head contrast with laser-evoked responses.

Perchet C., Hagiwara K., Salameh C., Garcia-Larrea L.

European Journal of Pain (0) 1-17.

The Association Between the Patient Self-Report Survey for the Assessment of Fibromyalgia with Pain Sensitivity and Psychological Factors in Individuals with Musculoskeletal Pain

Wilson, Abigail T; Razzell, Charlotte; Hanney, William J

Journal of Pain Research, Volume 16, 3297-3308. DOI: 10.2147/jpr.s425687

Cooling the skin for assessing small-fibre function.

Leone C., Dufour A., Di Stefano G., Fasolino A., Di Lionardo A., La Cesa S., Galosi E., Valeriani M., Nolano M., Cruccu G. Truini A.

Pain. 160(9), 1967-1975

Human brainstem activation underpinning offset analgesia changes in perceived pain intensity.

Crawford L. S., Kang J. WM, Wake A. H., Love T., Macey P. M., Bannister K., Wager T., Macefield V. G., Keay K, Henderson, L. A.

An ultra-high field functional magnetic resonance imaging investigation. Neuroimage. 335, 1-11.

Protokoll

Brain mechanisms supporting mindfulness-based chronic pain relief: A randomized, sham-mindfulness meditation controlled mechanistic clinical trial protocol

Dean, Jon G.; Allen, Alessandro; Barrows, Daniel; Birenbaum, Julia; Castellanos, Joel; Chakravarthy, Krishnan; Chen, Conan; Cruanes, Gael F.; Dhillon, Subber; Esshaki, Yasmeen; Fuentes, Richard; Furnish, Timothy; Gianola, Morgan; Jacobson, Aaron; Kim, Hyun-Chung; Khatib, Lora; Liu, Thomas; Lopez, Carolina; Miller, Jennifer; Mosbey, Dwayne; Oliva, Valeria; Patterson, Marta; Riegner, Gabriel; Wallace, Mark; Zeidan, Fadel

Contemporary Clinical Trials Communications, 52, 101665. DOI: 10.1016/j.conctc.2026.101665

I feel your pain: higher empathy is associated with higher posterior default mode network activity

Oliva, Valeria; Riegner, Gabriel; Dean, Jon; Khatib, Lora A.; Allen, Alessandro; Barrows, Daniel; Chen, Conan; Fuentes, Richard; Jacobson, Aaron; Lopez, Carolina; Mosbey, Dwayne; Reyes, Mikaila; Ross, Jacob; Uvarova, Alexandra; Liu, Thomas; Mobley, William; Zeidan, Fadel

Pain, 166(4), e60-e67. DOI: 10.1097/j.pain.0000000000003434

Modulating subjective pain perception with decoded Montreal Neurological Institute-space neurofeedback: a proof-of-concept study

Berman, Taryn; Cushing, Cody; Manuel, Shawn; Vachon-Presseau, Etienne; Cortese, Aurelio; Kawato, Mitsuo; Woo, Choong-Wan; Wager, Tor Dessart; Lau, Hakwan; Roy, Mathieu; Taschereau-Dumouchel, Vincent

Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1915), 20230082. DOI: 10.1098/rstb.2023.0082

Intrinsic network activity reflects the fluctuating experience of tonic pain

Deak, Bettina; Eggert, Thomas; Mayr, Astrid; Stankewitz, Anne; Filippopulos, Filipp; Jahn, Pauline; Witkovsky, Viktor; Straube, Andreas; Schulz, Enrico

Cerebral Cortex, 32(18), 4098-4109. DOI: 10.1093/cercor/bhab468

No effect of acute pain or self-reported chronic pain on working memory in the Sternberg task

Phelps, Caroline E.; Oliveira, Larissa E.; Ngo, Michelle N.; Medhi, Kera S.; Schoone, Stephanie; Debrosse, Devyn; Aragundi, Lizbeth; Delval, Alexe G. R.; Wilson, Robert C.

Scientific Reports, 16(1), 28988. DOI: 10.1038/s41598-026-58342-z

Bilateral Long-Lasting Changes in Multimodal Sensitivity After Cutaneous High-Frequency Electrical Stimulation: A New Comprehensive Dermatomal Examination

Escobar-Sánchez, Isabel; Taylor, Julian; Fernández-Pérez, Juan José; Ríos-León, Marta

Journal of Clinical Medicine, 15(19), 7425. DOI: 10.3390/jcm15197425

Protokoll

Understanding Motor Adaptation in the Transition to Sustained Pain: Protocol for a Longitudinal Experimental Study

Duport, Arnaud; Phylactou, Phivos; Diotalevi, Gaspard; Arseneau, Dryden; Ngoc Minh Pham, Thu; Lowndes, Ashley; Espin-Garcia, Osvaldo; Seminowicz, David A; Schabrun, Siobhan M

JMIR Research Protocols, 15, e99833-e99833. DOI: 10.2196/99833

Effects of Aging on Pain Tolerance: A Comparative Study of Heat Pain Thresholds and Tonic Heat and Cold Stimuli

Devanne, Julia; Trocmet, Louise

European Journal of Pain, 30(1), e70180. DOI: 10.1002/ejp.70180

Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities

Hamilton, Rebecca I.; Garcia, Ashly Alava; Bowd, Jake; Hamilton, David; Mason, Deborah; Elliott, Mark; Holt, Cathy

BMC Research Notes, 17(1), 36. DOI: 10.1186/s13104-024-06689-9

Spatial summation of cold and warm detection: Evidence for increased precision when brisk stimuli are delivered over larger area

Courtin, Arthur S.; Delvaux, Aurore; Dufour, Arthur; Mouraux, André

Neuroscience Letters, 797, 137050. DOI: 10.1016/j.neulet.2023.137050

Accurate determination of the cold detection threshold with high-speed cooling of the skin.

Lithfous S., Després O., Pebayle T., Casadio C. & Dufour A.

Pain Medicine. online ahead of print.

Modification of descending analgesia in aging: critical role of the prefrontal cortex.

Lithfous S., Després O, Pebayle T. & Dufour A.

Clinical Journal of Pain . 35(1), 23-30.

Effects of thermosensory aging well demonstrated by cold stimulation with high temporal resolution.

Després O, Lithfous S, Pebayle T. Casadio C. & Dufour A.

Muscle Nerve. 60(2) ., 141-146.

The thermal grill elicits central sensitization.

Cormie M.A., Seminowicz D.A., Moayedi M.

Pain. 166(12):2756-2770.

Assessing individual sensitivity to the Thermal Grill Illusion: A two-dimensional adaptive psychophysical approach.

Sardeto Deolindoa C., Fischer Ehmsena J., Courtina A., Mitchella A., Kraengea C., Nikolovaa N., Allena M., Fardo F.

The Journal of Pain. 27, 1 - 11.

It is one or the other: No overlap between healthy individuals perceiving thermal grill illusion or paradoxical heat sensation.

Schaldmose E., Raaschou-Nielsen L., Böhme R., Finnerup N. & Fardo F.

ENeuroscience Letters . 802, 1-7.

Thermal sensitivity in humans at the depth of thermal receptor endings beneath the skin: validation of a heat transfer model of the skin using high-temporal resolution stimuli.

Dufour A., Després O, Pebayle T. & Lithfous S.

European Journal of Applied Physiology . 120, 1509-1518.

A distributed coding logic for thermosensation and inflammatory pain.

Ghitani N, Buchholtz L.J., MacDonald D., Falgairolle M., Nguyen M.Q., Licholai J.A., Ryba, N.J.P., Chesler A.T.

Nature. 642, 1016-2023.

The cellular coding of temperature in the mammalian cortex.

Vestergaard M, Carta M, Güney G, Poulet JFA.

Nature. 2023 Feb;614(7949):725-731. doi: 10.1038/s41586-023-05705-5. Epub 2023 Feb 8.

Nociception in Chicken Embryos, Part II: Embryonal Development of Electroencephalic Neuronal Activity In Ovo as a Prerequisite for Nociception

Kollmansperger, Sandra; Anders, Malte; Werner, Julia; Saller, Anna M.; Weiss, Larissa; Süß, Stephanie C.; Reiser, Judith; Schneider, Gerhard; Schusser, Benjamin; Baumgartner, Christine; Fenzl, Thomas

Animals, 13(18), 2839. DOI: 10.3390/ani13182839

Spinal integration of hot and cold nociceptive stimuli by wide dynamic range neurons in anesthetized adult rats.

Gieré C., Melchior M., Dufour A., Poisbeau P.

Pain Reports. Epub.